Single Nucleotide Polymorphism E23K of KCNJ11 Gene and Other Risk Factors Associated With Type-2 Diabetes Mellitus In Gaza

Abed, Abdalla A and Ayesh, Basim and Hamdona, Osama (2013) Single Nucleotide Polymorphism E23K of KCNJ11 Gene and Other Risk Factors Associated With Type-2 Diabetes Mellitus In Gaza. Int. J. Chem. and Life Sciences, 2 (4). pp. 1146-1152.

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Abstract

Type 2 diabetes mellitus (T2DM) is a multifactorial disease in which environmental triggers interact with genetic variants in predisposition to disease. The aim of this study was to evaluate (E23K) SNP in KCNJ11 gene as a possible contributor to T2DM among Gaza City patients. Also to consider relation between E23K SNP and other risk factors for T2DM. Two hundred male and female individuals were examined: 100 T2DM patients and 100 control individuals. The glucose level was determined, and the groups were genotyped for the SNP (E23K) by PCR/RFLP technique using the BanII restriction enzyme. A questionnaire was completed to evaluate the role of physical and environmental risk factors for T2DM. There was a strong statistically significant relation between the E23K polymorphism and T2DM (P=0.000). Forty three percent of cases were E/K compared to 29% of controls; and 15% of cases were K/K compared to 3% of controls. Obesity, persistent stress, absence of physical activity and low level of education were also significantly related to T2DM (P=0.000). The mean fasting blood sugar level was significantly higher among the cases than the control, and particularly among homozygous and heterozygous cases (P= 0.000). In conclusion, risk factors that are significantly related with T2DM patients in Gaza city include the E23K polymorphism, obesity, persistent stress, absence of physical activity, and low level of education. The inheritance of the K allele predisposes for T2DM, provided that other genetic or/and physical and environmental risk factors be present.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: د. باسم محمد حسين عايش
Date Deposited: 16 Apr 2018 06:45
Last Modified: 16 Apr 2018 06:45
URI: http://scholar.alaqsa.edu.ps/id/eprint/664

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