Evaluation of- and-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine.

Ayesh, Basim Mohammad and Abu Shaaban, Ahmed Shaker and Abed, Abdalla Asaf (2018) Evaluation of- and-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine. Future science OA, 4 (3). FSO276. ISSN 2056-5623

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Official URL: https://www.future-science.com/doi/10.4155/fsoa-20...

Abstract

Aim To evaluate applicability of,andbased algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients. Patients & methods Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD. Results Frequency of,andalleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE = 8.9 ± 1.4; R = 0.350) than both the clinical algorithm (MAE = 10.4 ± 1.4; R = 0.128;) and the fixed-dose algorithm (MAE = 11.1 ± 1.7). Conclusion The international warfarin pharmacogenetics consortium algorithm can be reliably applied for predicting the WSD in Palestinian population.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Depositing User: د. باسم محمد حسين عايش
Date Deposited: 16 Apr 2018 06:45
Last Modified: 16 Apr 2018 06:45
URI: http://scholar.alaqsa.edu.ps/id/eprint/659

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