Some Hematological And Biochemical Changes Associated With Aspirin Administration In Albino Rats بعض التغيرات الدموية والبيوكيميائية المصاحبة لإعطاء الأسبرين في الجرذان البيضاء

اليازجي, نهاد and عبد العزيز, اسماعيل and عاشور, عبد الرحيم (2015) Some Hematological And Biochemical Changes Associated With Aspirin Administration In Albino Rats بعض التغيرات الدموية والبيوكيميائية المصاحبة لإعطاء الأسبرين في الجرذان البيضاء. Al-Aqsa University Journal (Natural Sciences Series), 19 (1). pp. 63-76. ISSN 2070-3155 (Print), ISSN 2521-893X (Online)

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Abstract

The present work investigated the effect of daily oral administration of aspirin (324 mg/kg body wt. /day)for 10 weeks on complete blood picture and some biochemical parameters of male albino rats. Daily oral administration of aspirin provoked a general increase in white blood cells count (WBC)and blood platelets count (PLT) with percentage changes of 9.24 & 24.52% compare to control respectively. Whereas, red blood cells count (RBC), hemoglobin content (Hb), hematocrit (HCT) values the mean corpuscular volume(MCV)and mean corpuscular hemoglobin(MCH)showed significantly decrease (p<0.01) compared to the control level. The concentrations of urea, uric acid, creatinine, calcium and potassium were elevated due to aspirin administration, while serum glucose, total cholesterol, triacylglycerols , total proteins, sodium and alkaline phosphatase (ALP)activity were decreased. Key words:Aspirin, hematological parameters, Alkaline phosphatase, kidney function, albino rats

Item Type: Article
Subjects: Q Science > QE Geology
Depositing User: أ. دارين علي أحمد حمد
Date Deposited: 05 Sep 2021 10:09
Last Modified: 31 Oct 2021 10:38
URI: http://scholar.alaqsa.edu.ps/id/eprint/6522

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