Histological, Histochemical and Ultrastructural Studies on the Kidney of Rats After Administration of Monosodium Glutamate

AlAgha, Salam Zakaria (2006) Histological, Histochemical and Ultrastructural Studies on the Kidney of Rats After Administration of Monosodium Glutamate. Al-Aqsa University Journal (Natural Sciences Series), 10 (S.E.). pp. 20-40. ISSN ISSN 2070-3155 (Print), ISSN 2521-893X (Online)

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The present investigation demonstrated the effect of oral administration of two different doses of monosodium glutamate (MSG): 2 mg/g/b.w. and 3mg/g/b.w. for 21 and 45 days respectively on the histological structure of the kidney tissues of adult male albino rats. The histopathological observation of the kidney tissues after the dministration of 2mg/g/b.w., showed partial loss of brush border of proximal convoluted tubules and necrotic lesions in the epithelial lining of renal tubules. Numerous inflammatory cells infiltrated in the interstitial tissues and pyknotic, karryolysed nuclei in some tubules were also observed. Severe histopathological lterations were recorded after treatment of rats with 3mg/g/b.w. of MSG. These changes included distention of glomerular capillaries with fat globules, distortion of renal architecture in most of the cells, lobulation in some glomerular tufts with haemorhogic lesions, shrunken glomeruli which invaginated by fatty globules and diffused hyaline thickening of capillary endothelium .Histochemical investigations revealed marked reduction in both carbohydrates and proteins after the treatment with MSG. Ultrastructural studies revealed destruction of cytoplasmic organelles, thickening of the basement membrane of the proximal convoluted tubules and irregularly- shaped nuclei. الملخص : دراسة هستولوجية وهستوكيميائية ودقيقة على كلية الفئران بعد معالجتها بجلوتاميد أحادي الصوديوم.

Item Type: Article
Uncontrolled Keywords: Sodium glutamate, histochemistry, histopathology, Ultrastructure, kidney.
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mr. Ahmed A, Ouda
Date Deposited: 05 Apr 2018 07:16
Last Modified: 09 Apr 2018 07:32
URI: http://scholar.alaqsa.edu.ps/id/eprint/646

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