التغیرات الكیموحیویة والنسیجیة المصاحبة للمضاد الحیوي الأموكسیسیلین ومسكن الباراسیتامول وخلیطھما على الأرانب

Abu btehan, Nour S (2018) التغیرات الكیموحیویة والنسیجیة المصاحبة للمضاد الحیوي الأموكسیسیلین ومسكن الباراسیتامول وخلیطھما على الأرانب. Masters thesis, الجامعة الإسلامية بغزة.

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Abstract

Background and Problem: The extensive misuse of antibiotic and analgesic for treatment lead to many health problems especially for liver and kidney function. Objectives and aims: The study characterizes biochemical changes and histological examination associated with chronic toxicity of Amoxicillin, Paracetamol and their mixture in rabbits. Methodology: Specific oral dose of Amoxicillin (8 mg/kg), Paracetamol (24mg/kg), and their mixture (8+24mg/kg) were given to three groups of rabbits to 2 weeks period and left for 6 weeks without treatment, fourth group left as control group. The physical and morphological features of the tested animal was monitored during the eight weeks. Then the animals were sacrificed, blood samples were collected in heparinized tubes until analysis. Then liver, kidney and heart were collected, washed with saline solution, weighted and grounded in saline solution for histological examination. Evaluation of toxicity was determined by analyzing the levels of the following enzymes and compounds in the collected blood serum: Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphates (ALP), Total protein, creatinine, uric acid, and urea using commercially available kits. Results: showed reduced weights of rabbits due to Amoxicillin, Paracetamol, and their mixture administration. The effect of mixture (2655±400.44) in reducing rabbit's weight was more pronounced than in Amoxicillin or Paracetamol. All treatments increased the weight of liver and significant elevation was observed in Paracetamol (105±8.66) then mixture (95.00±13.23) treatments, also the heart weight of rabbit was showed reduced in all treatments which have approximately similar heart weights (13.33±2.89) compared with control (15.00±5). The observation of kidney weight was showed decreased in Amoxicillin (18.33±2.89) and mixture treatments (19.00±1.73) when compared with control group (20.00±5) except

Item Type: Thesis (Masters)
Subjects: Q Science > QE Geology
Depositing User: أ. دارين علي أحمد حمد
Date Deposited: 01 Mar 2021 12:00
Last Modified: 01 Mar 2021 12:00
URI: http://scholar.alaqsa.edu.ps/id/eprint/3922

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