تقييم مستوى إنزيم الكورين وبعض المعايير البيوكيميائية لدى مرضى الكلى المزمن من الأطفال الذكور في قطاع غزة

Muhanna, Hanaa Mohammed (2017) تقييم مستوى إنزيم الكورين وبعض المعايير البيوكيميائية لدى مرضى الكلى المزمن من الأطفال الذكور في قطاع غزة. Masters thesis, الجامعة الإسلامية بغزة.

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Abstract

Background: Chronic kidney disease (CKD) has been recognized as considerable medical problems for most of the last two centuries. This study investigates serum corin levels in CKD patients, revealing higher levels than in normal individuals. Objective: To assess corin level in patients with CKD and controls from Gaza Strip, and its relationships with some biochemical variables. Subject and methods: This case-control study comprised 43 cases and 43 controls males below 12 years old. Questionnaire interview was applied. Serum corin, urea, creatinine, uric acid, total protein, albumin, cholesterol, triglyceride, phosphorus, calcium, sodium, potassium and chloride were determined. Data were computer analyzed using SPSS version 22.0. Results: The mean of cases age was 6.1±3.6 years compared to 6.6±3.3 years of controls (P=0.540). Serum corin was progressively increased showing mean of 1816.3±782.3 pg/ml in cases and mean of 1359.1±442.2 pg/ml in controls. The difference in body mass index (BMI) between cases and controls was highly significant (16.1±2.7 vs. 20.6±3.5 kg/m2 respectively, P<0.001).The mean of glomerular filtration rate (GFR) was found to be significantly higher in controls compared to cases (143.2±31.9 vs. 57.8±51.4 ml/min/1.73m² respectively, P<0.001). The mean of cholesterol was found to be significantly higher in cases compared to controls (195.4±80.4 vs.159.7±28.9 mg/dl respectively, P=0.007). In addition, triglyceride was significantly higher in cases than in controls (173.1±133.1 vs. 108.4±42.9 mg/dl respectively, P=0.003). There was a significant difference in the calcium level between cases and controls (9.1±1.2 vs. 10.6±0.9 mg/dl respectively, P<0.001). The Pearson correlation test showed positive significant correlation between corin level and urea (r=0.224, P=0.038). ) The Pearson correlation test also showed positive correlation with onset CKD and systolic blood pressure but it was not significant (r=0.174, P=0.264 and r=0.029 respectively, P=0.789). Conclusions: Serum corin was significantly higher in CKD patients compared to controls. Serum corin level has a significant inverse relation with age, height, weight, BMI, total protein, calcium, and GFR. In contrast, Serum corin levels showed significant positive correlations with urea and phosphorus. Keywords: Chronic kidney disease. Serum corin. Male children. Gaza strip.

Item Type: Thesis (Masters)
Subjects: Q Science > QE Geology
Q Science > QR Microbiology
Depositing User: أ. دارين علي أحمد حمد
Date Deposited: 01 Mar 2021 11:59
Last Modified: 01 Mar 2021 11:59
URI: http://scholar.alaqsa.edu.ps/id/eprint/3892

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