عوامل التجلط في النساء الحوامل طبيعيا في قطاع غزة

Musallam, Elham Salem (2016) عوامل التجلط في النساء الحوامل طبيعيا في قطاع غزة. Masters thesis, الجامعة الإسلامية بغزة.

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Abstract

Background: Normal pregnancy has been associated with alteration of the hemostatic system. Pregnancy is recognized as a hypercoagulable state that protect women from potentially hemorrhage during placentation and the post-partum period. Objective: To assess hemostatic profile of normal pregnant women in Gaza strip. Materials and methods: This case-control design study included 105 healthy pregnant women subdivided into three groups each consists of 35 women comprising 1st, 2nd and 3rd trimesters, and 35 healthy non-pregnant women. Questionnaire interviews were applied. Hemostatic profiles were assessed. Data were computer analyzed using SPSS program version 21. Results: The mean ages of controls and pregnant women in the first, second and third trimesters were 29.0±5.1, 28.6±6.2, 28.7±5.8 and 28.9±6.1 years old, respectively. Unemployment women and lower family income were more prevalent among pregnant women (P=0.004 and P=0.002, respectively). Diastolic blood pressure recorded significant decrease in pregnant women compared to non-pregnant women (P=0.031). PT and INR were significantly decreased as pregnancy progress (P=0.001). Conversely, fibrinogen was significantly elevated in the 1st, 2nd and 3rd trimesters compared to controls (P=0.001). RBCs count, Hb, platelets count, lymphocytes count and Ca concentration showed significant decrease in the three trimesters of pregnancy compared to controls (P=0.001, P=0.001, P=0.001, P=0.001 and P=0.003, respectively). Whereas there were significant increases in the means of WBCs count, MID cells, granulocytes count and ESR in the three trimesters of pregnancy compared to controls (P=0.002 for WBC; P=0.030 for MID cells, P=0.001 for granulocyte and P=0.001 for ESR). Similarly there was significant increase in MCV in the 3rd trimester compared to the 1s trimester (P=0.006). MCHC displays significant increases in the 1st trimester with respect to controls and then significant decreases was recorded in the 2nd and 3rd trimesters compared to 1st trimester (P=0.001). The Pearson correlation coefficient test showed significant positive correlations of fibrinogen with WBC (r=0.196, P=0.045), Granulocyte (r=0.219, P=0.025) and ESR (r=0.260, P=0.007) in pregnant women. Conclusions: Hemostatic parameters were altered during pregnancy. There were significantly increases in fibrinogen, WBC, MID, granulocytes, MCV and ESR during pregnancy. In contrast PT, INR , lymphocytes, RBC, Hb, Hct, MCHC, platelets and calcium were significantly deceased. Fibrinogen showed significant positive correlations with WBC, granulocyte and ESR.

Item Type: Thesis (Masters)
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
Depositing User: أ. دارين علي أحمد حمد
Date Deposited: 01 Mar 2021 11:50
Last Modified: 01 Mar 2021 11:50
URI: http://scholar.alaqsa.edu.ps/id/eprint/3759

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