مستوى الفازبين في مصل الدم لمرضى السكرى من النوع الثاني في قطاع غزة

Alborno, Najwa Talal (2016) مستوى الفازبين في مصل الدم لمرضى السكرى من النوع الثاني في قطاع غزة. Masters thesis, الجامعة الإسلامية بغزة.

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Abstract

Background: Type 2 diabetes is prevalent in Gaza strip. Recently, vaspin has been identified as interesting novel adipokine having insulin sensitizing effect. However, the relationship between vaspin and type 2diabetes have not been adequately studied. Objective: To assess serum vaspin level in type 2 diabetic patients from Gaza Strip, and its relationships with some biochemical variable. Materials and methods: This case-control study comprised 88 type 2 diabetic patients (44 males and 44 females) and 88 healthy controls (44 males and 44 females). Questionnaire interview was applied. Serum vaspin, glucose, blood glycated hemoglobin (HbA1c), insulin, cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, creatinine and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) were determined. Data were computer analyzed using SPSS version 22.0. Results: The mean ages of cases and controls were 45.9±7.1 and 45.8±7.0 years, respectively. The mean level of vaspin was significantly higher in cases compared to controls (0.73±0.67 versus 0.47±0.43 ng/ml, P=0.033). Obese diabetic patients showed higher vaspin levels compared to controls (0.99±0.7 versus 0.62±0.52 ng/ml, P=0.048). Vaspin was also significantly increased in obese cases compared to non obese cases (0.99±0.7 versus 0.48±0.42 ng/ml, P=0.005). The levels of blood HbA1c, serum glucose and HOMA-IR were significantly increased in cases compared to controls (6.7±1.3 versus 4.7±0.65%, P=0.000 and 189.6±79.1 versus 90.7±13.6 mg/dl, P=0.000, 8.0±7.3 versus 3.6±2.4, P=0.000, respectively). The mean levels of triglycerides was significantly higher in cases compared to controls (187.6±133.8 versus 133.7±71.8 mg/dl, P=0.021) whereas HDL-C was significantly lower in cases (45.3±10.3 versus 50.8±13.8 mg/dl, P=0.039). Serum vaspin levels showed significant positive correlations with BMI (r=0.280, P=0.008), HbA1c% (r=0.209, P=0.049), glucose (r=0.290, P =0.006 ), HOMA-IR (r=0.276, P=0.010), triglycerides (r=0.303, P=0.004) and ALT activity (r=0.434, P=0.000). Conclusions: Serum vaspin was significantly higher in type 2 diabetic patients compared to controls. Serum vaspin levels showed significant positive correlations with BMI, HbA1c, glucose, HOMA-IR, triglycerides and ALT. Keywords: Type 2 diabetic patients, Serum vaspin, Gaza strip.

Item Type: Thesis (Masters)
Subjects: Q Science > QE Geology
R Medicine > R Medicine (General)
Depositing User: أ. دارين علي أحمد حمد
Date Deposited: 01 Mar 2021 11:30
Last Modified: 01 Mar 2021 11:30
URI: http://scholar.alaqsa.edu.ps/id/eprint/3754

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