Determination of haloperidol drug in ampoules and in urine samples using a potentiometric modified carbon paste electrode

Abu Shawish, Hazem M. and Abed Almonem, Khaled I. and Saadeh, Salman M. and Al-lham, Wael S. (2016) Determination of haloperidol drug in ampoules and in urine samples using a potentiometric modified carbon paste electrode. Measurement, 78. pp. 180-186. ISSN 02632241

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Abstract

A modified carbon paste electrode for haloperidol drug based on haloperidol-phosphomolybdate (HP-PM) as an ion-exchanger dissolved in plasticizer DBP and its potentiometric characteristics were discussed. The electrode exhibited a good Nernstian slope of 56.9 ± 0.3 mV/decade with a linear concentration range from 3.2 × 10−6 to 1.0 × 10−2 M for the haloperidol ion. The limit of detection (LOD) was 1.5 × 10−6 M. It had response time of 5–8 seconds (s), useable in pH range of 6.2–8.6 and temperature of 20–60 °C. The electrode shows clear discrimination of haloperidol drug from several inorganic ions, sugars and some common drug excipients. The sensor was applied for determination of haloperidol drug in urine and in pharmaceutical formulations using potentiometric determination, standard addition and the calibration curve methods. The results are satisfactory with excellent percentage recovery comparable or better than those obtained by other routine methods.

Item Type: Article
Subjects: Q Science > QD Chemistry
Depositing User: أ.د. حازم محمد عبد الحميد أبو شاويش
Date Deposited: 12 Mar 2018 15:51
Last Modified: 12 Mar 2018 15:51
URI: http://scholar.alaqsa.edu.ps/id/eprint/372

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