Some Hematological And Biochemical Changes Associated With Aspirin Administration In Albino Rats

Elyazji, Nehad R. and Abdel-Aziz, Ismail and Ashour, Abdelrahiem A. (2015) Some Hematological And Biochemical Changes Associated With Aspirin Administration In Albino Rats. Al-Aqsa University Journal (Natural Sciences Series), 19 (1). pp. 63-76. ISSN ISSN 2070-3155 (Print), ISSN 2521-893X (Online)

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Abstract

The present work investigated the effect of daily oral administration of aspirin (324 mg/kg body wt. /day)for 10 weeks on complete blood picture and some biochemical parameters of male albino rats. Daily oral administration of aspirin provoked a general increase in white blood cells count (WBC)and blood platelets count (PLT) with percentage changes of 9.24 & 24.52% compare to control respectively. Whereas, red blood cells count (RBC), hemoglobin content (Hb), hematocrit (HCT) values the mean corpuscular volume(MCV)and mean corpuscular hemoglobin(MCH)showed significantly decrease (p<0.01) compared to the control level. The concentrations of urea, uric acid, creatinine, calcium and potassium were elevated due to aspirin administration, while serum glucose, total cholesterol, triacylglycerols , total proteins, sodium and alkaline phosphatase (ALP)activity were decreased.

Item Type: Article
Uncontrolled Keywords: Aspirin, hematological parameters, Alkaline phosphatase, kidney function, albino rats.
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Engineering, Science and Mathematics > School of Physics
Depositing User: Mr. Ahmed A, Ouda
Date Deposited: 16 Jan 2018 08:51
Last Modified: 18 Mar 2018 12:15
URI: http://scholar.alaqsa.edu.ps/id/eprint/34

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