Non Alcoholic Fatty Liver Disease and Its Connection with Diet Habit, Insulin Resistance and Dyslipidemia

Abd ELnabi, Hana (2015) Non Alcoholic Fatty Liver Disease and Its Connection with Diet Habit, Insulin Resistance and Dyslipidemia. Masters thesis, Al Azhar University Gaza.

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Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is closely linked with obesity and insulin resistance. Dietary patterns and nutrients are the important contributors to the development and treatment of NAFLD. Objectives: This study was conducted to identify the effect of diet and dietary habits in occurrence of NAFLD, to reveal the connection of NAFLD with insulin resistance, to clarify the connection between NAFLD and dyslipidemia and to raise dietary recommendations and advices to mitigate NAFLD. Methodology: A retrospective case-control study was conducted at ultrasound centers at governmental hospitals in Gaza Strip. The study consisted of 55 cases of NAFLD and 55 age matched controls. Data collection was done by direct methods that included fasting blood sugar, lipid profile, liver enzymes and hepatitis B surface antigen, and indirect methods through a structured interview questionnaire. Results: Concerning dietary factors, intake of fast food, sweets, soft drinks and high intake of carbohydrates and fats were positively correlated with NAFLD (P value= 0.001 for each). About biochemical tests, high serum levels of Aspartate Aminotransferase (AST) and high Fasting blood sugar (FBS) were positively correlated with NAFLD (P value = 0.001 for both), while low High-density lipoprotein cholesterol (HDL-C) levels were inversely correlated with NAFLD (P value= 0.02). Other factors were positively associated with NAFLD such as: hypertension (36.4% of cases versus 16.4% of controls [P value= 0.02]), Diabetes mellitus ( 25.5% of cases versus 3.6% of controls [P value= 0.01]), hyperlipidemia ( 40% of cases and none of controls [P value= 0.001]), and obesity ( 80% of cases compared to 25.5% of controls [ P value =0.001]). About lifestyle, 76.4% of cases were physically inactive versus 54.5% of controls (P value= 0.01). Conclusion: Many risk factors including a diet high in carbohydrates (such as sweets and soft drinks) and fats. Diabetes mellitus, hyperlipidemia and obesity may be associated with the development of NAFLD. Recommendation: For health providers is recommended performing serum transaminases level and liver ultrasound in patients with obesity, Diabetes and hyperlipidemia for early detection of NAFLD. Key words: Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus, Obesity, Hyperlipidemia, Gaza Strip.

Item Type: Thesis (Masters)
Subjects: Q Science > Q Science (General)
Depositing User: أ. طارق زياد عبد حنونة
Date Deposited: 18 Aug 2020 08:51
Last Modified: 18 Aug 2020 08:51
URI: http://scholar.alaqsa.edu.ps/id/eprint/2059

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