Comparative study between nebulised Salbutamol versus nebulised Adrenaline in the treatment of acute bronchiolitis in Pediatrics in El-Nasser Pediatric hospital in Gaza

Enaya, Ola Tawfiq (2010) Comparative study between nebulised Salbutamol versus nebulised Adrenaline in the treatment of acute bronchiolitis in Pediatrics in El-Nasser Pediatric hospital in Gaza. Masters thesis, Al Azhar University Gaza.

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Abstract

Acute bronchiolitis is considered as an important lower respiratory tract infection, especially in children younger than 6 months of age. Its clinical picture resembles asthma because of rhinorhoea, wheezing and tachypnoea. This similarity has affected the treatment modalities of acute bronchiolitis, and has caused bronchodilators to be used commonly in its management. The aim of this prospective study is to compare the effectiveness of two common bronchodilators widely used in our community. Nebulised adrenaline and nebulised salbutamol, as they are commonly prescribed by our pediatricians on equal basis without differentiation . To achieve this, 220 hospitalized patients diagnosed clinically and with laboratory measurements as acute bronchiolitis, 114 patients were treated with nebulised salbutamol (72 Males, 42 Females), 106 patients treated with nebulised adrenaline (61 males, 45 Females) aged between 2-24 months old. Salbutamol inhalation was given four to six times daily by a dose of 0.15 mg/kg diluted in 3 mL saline, and Adrenaline inhalation prescribed at a dose of 0.1 mg/kg diluted in 3 mL normal saline administered to the patients every 6 hrs. by a special devise called nebulizer. All signs and symptoms were followed up for each admitted patient during the first 24 hrs. of treatment, for each bronchodilator used. Complete Blood Count was measured on admission for each patient, Arterial Blood Gases measured on admission, and after 4 and 24 hrs. following admission. The results showed that Adrenaline inhalation was more effective in improving O2 saturation percentage and O2 partial pressure, and it was also more effective in improving the main signs and symptoms as well as abbreviating the hospital stay of those patients. Therefore Adrenaline inhalation is recommended as the inhaled bronchodilator of choice to treat acute bronchiolitis in children. Key words : Acute bronchiolitis, inhaled bronchodilators, nebulized Salbutamol, nebulized Adrenaline, Complete Blood Count, Arterial Blood Gases, O2 saturation, O2 partial pressure.

Item Type: Thesis (Masters)
Subjects: Q Science > Q Science (General)
Depositing User: أ. طارق زياد عبد حنونة
Date Deposited: 18 Aug 2020 08:48
Last Modified: 18 Aug 2020 08:48
URI: http://scholar.alaqsa.edu.ps/id/eprint/2046

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