Effect of Omega-3 fatty acid supplementation during pregnancy on pregnancy outcome

El-Mallahi, Mohammed (2017) Effect of Omega-3 fatty acid supplementation during pregnancy on pregnancy outcome. Masters thesis, Al Azhar University Gaza.

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Abstract

Background: Obstetricians and multiple nutritional associations emphasis using of Omega-3 fatty acids (ω-3 FAs) supplementation during pregnancy. Objective: To determine whether ω-3 FAs supplementation during pregnancy have a beneficial role on pregnancy outcomes. Materials and methods: This study employed a clinical randomized controlled trial design, that conducted on 92 pregnant females that were stratified according to Number of pregnancies, Maternal age and Maternal Body Mass Index prior to pregnancy, and simple randomization for allocation into two groups (intervention and control group). The intervention group was received ω-3 FAs 300 mg/day from week 20 of gestation to delivery, Folic acid 400 mcg/day and Iron 27 mg/day from the beginning of pregnancy to the delivery. While the control group was supplemented with Folic acid 400 mcg/day and Iron 27 mg/day from the beginning of pregnancy to the delivery. Results: Results of the study showed a significant improvement in maternal biochemical investigations and pregnancy outcomes among intervention group compared with control group. There is significant increment in the Hemoglobin (p =0.029), in addition to significant reduction of Triglycerides levels (TGs) (p =<0.001) after 4 months of intervention, and in the TGs level (p =<0.001) after 8 weeks of delivery. Also, There is control in the Gestational Weight Gain during pregnancy (P=0.016) and a significant reduction of Systolic Blood Pressure(p =0.017) after 4 months of intervention. These significant improvements showed in the intervention group when compared with the control group after intervention period. Moreover, ω-3 FAs supplementation associated with improvement in infant anthropometrics, There was a healthy significant increase in Weight (p =<0.001), Length (p =<0.001), and head circumference (p =<0.001) in the intervention group when compared with the control group at the three measurements. In contrast, there is no statistical differences between the groups in the gestational length (p =0.217) and in Diastolic Blood Pressure (p =0.089) at the three measurements after 4 months of intervention. VII Conclusion: There was a significant differences with better changes among the ω-3 FAs group compared with control group after 4 months of intervention program on pregnancy outcomes for mothers and their infants as well. Key words: Omega-3 fatty acids, Hemoglobin, Triglyceride, Infant anthropometrics.

Item Type: Thesis (Masters)
Subjects: Q Science > Q Science (General)
Depositing User: أ. طارق زياد عبد حنونة
Date Deposited: 18 Aug 2020 08:40
Last Modified: 18 Aug 2020 08:40
URI: http://scholar.alaqsa.edu.ps/id/eprint/2013

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