Impact of Statins on metabolic syndrome patients in UNRWA primary health care in GAZA

Ramadan, Abeer shawki Hasan (2017) Impact of Statins on metabolic syndrome patients in UNRWA primary health care in GAZA. Masters thesis, Al Azhar University Gaza.

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Background: Metabolic syndrome is a multi-component disorder associated with a high risk of atherosclerotic cardiovascular disease. Its etiology is the result of a complex interaction between genetic and environmental factors, including dietary habits, insulin resistance, hyperlipidemia and visceral obesity. Statins are lipid lowering drugs used to decrease the cardiovascular complication in high risk patients with dyslipidemia. Objectives: Comparative study to evaluate the overall effect of statins on metabolic syndrome patients, and on blood glucose level over six months of treatment. Methodology: To achieve this purpose, eighty-eight patients with metabolic syndrome were selected. The study population was divided into two groups, control group which consisted of thirty-seven (37) patients and the statins treated group (atorvastatin 20mg, atorvastatin 40mg and simvastatin 20mg) which consisted of fifty-one (51) patients. The study was carried out at the United Nations Relief and Works Agency (UNRWA) clinics in North Gaza and Indonesi hospital. A questionnaire interview was used to collect the different socio-demographic factors as age, gender, occupation, level of education, marital status, and medical history of chronic diseases. Biochemical tests were carried out on fasting blood glucose and lipid profile. Additionally, anthropometric measurements as height, weight, body mass index and waist circumference were performed. Results: The study showed a significant decrease in lipid components by statins as follows, triglyceride level decreased from (239.37±116.57mg/dl to 180.96±82.41mg/dl at six months), total cholesterol decreased from (210.±47.70mg/dl to 175.29±43.07mg/dl at six months), LDL-c from (119.51±44.95mg/dl to 101.33±38.36mg/dl at six months) and non-HDL-c from (167.39±46.73mg/dl to 135.84±43.44mg/dl at six months). Insignificant effects of statins on fasting blood glucose level, HDL-c level and also no effect on blood pressure were seen. Conclusion: The results indicated that statins are an effective treatment on metabolic syndrome patients due to their significant decrease in lipid components. There was no significant effect of statins on fasting blood sugar, two new cases of diabetes mellitus out of twenty-one were discovered in statins treated group at three months. Recommendation: Metabolic syndrome is a serious problem and hence increased awareness is recommended. These patients need more studies and for longer periods to evaluate the effect of Statins on health. Keywords: Metabolic syndrome, Statins, cardiovascular disease.

Item Type: Thesis (Masters)
Subjects: Q Science > Q Science (General)
Depositing User: أ. طارق زياد عبد حنونة
Date Deposited: 18 Aug 2020 08:35
Last Modified: 18 Aug 2020 08:35

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