Possible association between non-alcoholic fatty liver disease and metabolic syndrome (case-control study)

Abu Hasanien, Suliman (2016) Possible association between non-alcoholic fatty liver disease and metabolic syndrome (case-control study). Masters thesis, Al Azhar University Gaza.

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Abstract

Non-Alcoholic Fatty Liver Disease (NAFLD) is a pathological status, that is defined as lipid accumulation in the cytoplasm of hepatocytes, where tri-acylglycerol (TG) accumulation inside the hepatocytes is the etiological factor for NAFLD. On the other hand, metabolic syndrome is defined as a collection of abnormalities combined with risk factors, such as obesity, lipid and carbohydrate metabolism disorders, and arterial hypertension. The present study aimed to find out possible association between non-alcoholic fatty liver disease and metabolic syndrome among adult males and females in Gaza and also to determine the prevalence of non-alcoholic fatty liver disease in Gaza. This is a case-control prospective study, adults who were diagnosed by a Radiologist with (NAFLD) in center of Gaza were included in this research. The study sample included 300 individuals (150 case, 150 healthy control), aged 35-65 years. Socio-demographic and clinical data were collected by questionnaire interview and venous blood sample were collected for biochemical analysis. For all study subjects, serum fast blood sugar (FBS), total cholesterol, triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were determined for overnight fasting venous blood. Body mass index (BMI), waist circumference (WC) and blood pressure (Bp) were measured. About two third of cases in this study who suffered of NFALD have metabolic syndrome (66%), while none of controls have the metabolic syndrome (0.0%). There is a significant difference between cases and control groups (χ2=147.761, VI P< 0.001). The overall prevalence of NAFLD was 7.14% of the study population, and it was significantly higher in women than in men (54.66 % and 45.43%, respectively). The highest percent of NAFLD cases was found in the age group 46-55 years (41.34%), followed by 35-45 years (30%) and 56-65 years (28.7%). There was a significant difference between the monthly income, smoking habit and food type of the cases and the controls (P=0.015, P< 0.001, P=0.004 respectively). More than half of NAFLD cases have significantly increased glucose level (54.66%) and inherited Diabetes Mellitus (52.66%) compared to controls (P < 0.001). Also, heart disease, (P< 0.001), inherited heart disease (P=0.001), cholesterol elevation (P< 0.001), triglyceride elevation (P<0.001), blood pressure elevation (P<0.001), inherited blood pressure elevation (P<0.001), increased ALT (P<0.001) and AST levels (P<0.001). About two-third of cases were not playing sport (66%) (P=0.001), and 76.7% were using drugs for treatment (P<0.001). The mean value of fasting blood glucose, cholesterol, triglyceride and low density lipoprotein in NAFLD cases was higher than in the controls, while the mean value of High Density Lipoprotein (HDL)in controls (52.02 mg/dl) was higher than in cases (37.70 mg/dl). NFALD disease was found to be significantly associated with metabolic syndrome. There was significant high number of NAFLD cases who smoke, having high blood glucose level, inherited Diabetes Mellitus, heart disease, inherited heart disease, high cholesterol level, high triglyceride level, blood pressure elevation, inherited blood pressure elevation and abnormal levels of liver enzymes AST and ALT. Keywords: Non-alcoholic fatty liver disease; Metabolic syndrome; Prevalence; Gaza.

Item Type: Thesis (Masters)
Subjects: Q Science > Q Science (General)
Depositing User: أ. طارق زياد عبد حنونة
Date Deposited: 18 Aug 2020 08:33
Last Modified: 18 Aug 2020 08:33
URI: http://scholar.alaqsa.edu.ps/id/eprint/1994

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