Physiological assessment of thyroid hormones and obesity among adult females in Gaza Governorates

Mousa, Raed Mustafa (2016) Physiological assessment of thyroid hormones and obesity among adult females in Gaza Governorates. Masters thesis, Al Azhar University Gaza.

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Abstract

The present study was aimed to assess the physiological change in thyroid hormones and obesity among adult females in Gaza governorates. The study was case-control design comprised 94 obese females aged between 20-50 years and equal number non-obese with matched age. Questionnaire interview was applied and BMI was determined. Blood samples for CBC, serum glucose, lipid and protein profile, kidney and liver function, Ca2+, TSH, T3 and T4 levels were measured using Cell-Dyne-1800, spectrophotometer, electrolyte analyzer and ELISA reader respectively. A permission from local ethical committee (Helsinki) to conduct this study was obtained. The results showed that average BMI of obese females (cases) was 37.23±4.7 compared to that of control was 23.4±1.03. Obesity was more prevalent among less educated and unemployed females, families with low income, as well as among smokers. The number of cases who had diabetes, hypertension, compliance of medication and take supplements or vitamins was significantly higher than control. Obesity was significantly related to treatment of thyroid gland problems, history of hyperlipidemia, inappropriate weight gain and family history (p<0.05). Getting fatigue quickly, muscle weakness, consumption of marine food, eating just before bed time and sleep problems were significantly related to obesity. Regular exercise and walking regularly were also related to obesity. WBC, PLT and RDW were increased in obese females compared to control. However, the increase in PLT and RDW was significant (p<0.05). RBC and MCHC were non significantly decreased whereas HGB, HCT MCV and MCH were decrease significantly in cases compared to control (P=0.001). The mean levels of glucose and HDL-C were non significantly whereas, the mean levels of TC, TG and LDL-C were significantly increased in cases compared to control (P=0.001). The mean levels of T. protein, albumin, globulin and uric acid non-significant increase in contrast, the mean levels of urea, creatinine, AST and ALT were found lower and non-significant in V cases compared to control (p>0.05). The mean level of TSH was significantly decreased in cases compared to control (% difference =-32.984 and P=0.001). In contrast, the mean levels of T3 and T4 were significantly increased among cases compared to control (% difference=9.485 and 6.326, p<0.05, respectively). After follow-up for six months among cases who used normal energy diet accompanied with regular exercise leading to weight loss. The results showed that BMI was significantly lower after weight loss than before with % = -39 and P=0.001. The percentage of change for TC, TG and LDL-C after weight loss were decreased significantly compared with before weight loss -12.3, -18 and -22, respectively. TSH was significantly increased after weight loss compared with mean before weight loss (3.2±1.7 Vs 2.05±0.6 μIU/ml, P=0.050 respectively). While, T3 and T4 were significantly decrease after weight loss in obese females compared to the mean before. BMI showed weak positive correlations with T3 and T4 levels and negative correlation with TSH (P<0.05). TSH showed a significant negative correlations with T3 and T4 (r=-0.509, -0.456, respectively, P=0.001). Strong positive correlation were obtained between T3 and T4 level (r=0.815, P=0.001). Normal energy diet accompanied with exercise induces a long term decrease in T3 & T4 and enhances TSH level. Physiological alterations seem to improve after weight loss and therefore no treatment is needed. Key words: Thyroid hormones, Thyroid stimulating hormone, Obesity, adult females, Gaza governorates.

Item Type: Thesis (Masters)
Subjects: Q Science > Q Science (General)
Depositing User: أ. طارق زياد عبد حنونة
Date Deposited: 18 Aug 2020 08:33
Last Modified: 18 Aug 2020 08:33
URI: http://scholar.alaqsa.edu.ps/id/eprint/1992

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